The immunophenotype.org data portal hosts several datasets providing insight into the function of the immune system. Select the dataset below to find out more information about the project and download the data.
Infection, Immunity, Immunophenotyping
The Infection, Immunity, Immunophenotyping (3i) project has established that genetics plays an important role in shaping the immune system. By using a high-throughput, high-density immunophenotyping platform we identified 140 genes (out of 530 screened) that have an impact on the immune system when knocked out in C57BL/6N mice.
The goal of the Covid-IP (Covid–ImmunoPhenotype) project is to better understand the immunophenotype, i.e., the status of the immune system, in persons who are or who have been infected with SARS-CoV-2 — the coronavirus responsible for Covid-19 disease.
Abeler-Dörner, L., Laing, A.G., Lorenc, A. et al. High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nat Immunol 21, 86–100 (2020). https://doi.org/10.1038/s41590-019-0549-0
Laing, A.G., Lorenc, A., del Molino del Barrio, I. et al. A dynamic COVID-19 immune signature includes associations with poor prognosis. Nat Med 26, 1623–1635 (2020). https://doi.org/10.1038/s41591-020-1038-6